Transglutaminase 4 as a prostate autoantigen in male subfertility

Economic strategies in modern male subfertility treatment.

Epidermal Transglutaminase (TGase 3) Is the Autoantigen of Dermatitis Herpetiformis

Gluten sensitivity typically presents as celiac disease, a common chronic small intestinal disorder. However, in certain individuals it is associated with dermatitis herpetiformis, a blistering skin disease characterized by granular IgA deposits in the papillary dermis. While tissue transglutaminase has been implicated as the major autoantigen of gluten sensitive disease, there has been no expl...

Absence of tektin 4 causes asthenozoospermia and subfertility in male mice.

Sperm flagellar motion is the outcome of a dynamic interplay between the axonemal cytoskeleton, the peri-axonemal accessory structures, and multiple regulatory networks that coordinate to produce flagellar beat and waveform. Tektins are conserved components of the flagellar proteome in evolutionarily diverse species and are believed to play essential roles in the mechanics of sperm motility. Us...

Reversible male subfertility due to hyperthyroidism.

A 26-year-old man with a one-year history of attempted conception was referred to a male subfertility clinic. Two previous semen analyses had disclosed oligospermia with sperm counts of 11 x 109/1 on both occasions (figure). He had had classical symptoms of thyrotoxicosis for five years and 18 months earlier had been investigated for palpitations. Examination showed a diffuse goitre, tremor, an...

Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis.

OBJECTIVE To determine the efficacy of varicocelectomy as a treatment for male factor infertility by improving the chance of spontaneous pregnancy. DESIGN Meta-analysis. SETTING Cleveland Clinic's Glickman Urological Institute. PATIENT(S) Infertile men with abnormal results on semen analyses and a palpable varicocele. INTERVENTION(S) Surgical varicocelectomy. MAIN OUTCOME MEASURE(S) S...